The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level
Identifieur interne : 000414 ( Main/Exploration ); précédent : 000413; suivant : 000415The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level
Auteurs :Source :
- JAMA Oncology [ 2374-2437 ] ; 2017.
Descripteurs français
- KwdFr :
- Années de vie ajustées sur la qualité (MeSH), Charge mondiale de morbidité (statistiques et données numériques), Consommation d'alcool (épidémiologie), Enregistrements (MeSH), Femelle (MeSH), Humains (MeSH), Hépatite B (complications), Hépatite B (épidémiologie), Hépatite C (complications), Hépatite C (épidémiologie), Incidence (MeSH), Mortalité (MeSH), Mâle (MeSH), Prévalence (MeSH), Santé mondiale (MeSH), Tumeurs du foie (épidémiologie), Tumeurs du foie (étiologie).
- MESH :
- statistiques et données numériques : Charge mondiale de morbidité.
- épidémiologie : Consommation d'alcool, Hépatite B, Hépatite C, Tumeurs du foie.
- étiologie : Tumeurs du foie.
- complications : Années de vie ajustées sur la qualité, Enregistrements, Femelle, Humains, Hépatite B, Hépatite C, Incidence, Mortalité, Mâle, Prévalence, Santé mondiale.
English descriptors
- KwdEn :
- Alcohol Drinking (epidemiology), Female (MeSH), Global Burden of Disease (statistics & numerical data), Global Health (MeSH), Hepatitis B (complications), Hepatitis B (epidemiology), Hepatitis C (complications), Hepatitis C (epidemiology), Humans (MeSH), Incidence (MeSH), Liver Neoplasms (epidemiology), Liver Neoplasms (etiology), Male (MeSH), Mortality (MeSH), Prevalence (MeSH), Quality-Adjusted Life Years (MeSH), Registries (MeSH).
- MESH :
- complications : Hepatitis B, Hepatitis C.
- epidemiology : Alcohol Drinking, Hepatitis B, Hepatitis C, Liver Neoplasms.
- etiology : Liver Neoplasms.
- statistics & numerical data : Global Burden of Disease.
- Female, Global Health, Humans, Incidence, Male, Mortality, Prevalence, Quality-Adjusted Life Years, Registries.
Abstract
Liver cancer is among the leading causes of cancer deaths globally. The most common causes for liver cancer include hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and alcohol use.
To report results of the Global Burden of Disease (GBD) 2015 study on primary liver cancer incidence, mortality, and disability-adjusted life-years (DALYs) for 195 countries or territories from 1990 to 2015, and present global, regional, and national estimates on the burden of liver cancer attributable to HBV, HCV, alcohol, and an “other” group that encompasses residual causes.
Mortality was estimated using vital registration and cancer registry data in an ensemble modeling approach. Single-cause mortality estimates were adjusted for all-cause mortality. Incidence was derived from mortality estimates and the mortality-to-incidence ratio. Through a systematic literature review, data on the proportions of liver cancer due to HBV, HCV, alcohol, and other causes were identified. Years of life lost were calculated by multiplying each death by a standard life expectancy. Prevalence was estimated using mortality-to-incidence ratio as surrogate for survival. Total prevalence was divided into 4 sequelae that were multiplied by disability weights to derive years lived with disability (YLDs). DALYs were the sum of years of life lost and YLDs.
Liver cancer mortality, incidence, YLDs, years of life lost, DALYs by etiology, age, sex, country, and year.
There were 854 000 incident cases of liver cancer and 810 000 deaths globally in 2015, contributing to 20 578 000 DALYs. Cases of incident liver cancer increased by 75% between 1990 and 2015, of which 47% can be explained by changing population age structures, 35% by population growth, and −8% to changing age-specific incidence rates. The male-to-female ratio for age-standardized liver cancer mortality was 2.8. Globally, HBV accounted for 265 000 liver cancer deaths (33%), alcohol for 245 000 (30%), HCV for 167 000 (21%), and other causes for 133 000 (16%) deaths, with substantial variation between countries in the underlying etiologies.
Liver cancer is among the leading causes of cancer deaths in many countries. Causes of liver cancer differ widely among populations. Our results show that most cases of liver cancer can be prevented through vaccination, antiviral treatment, safe blood transfusion and injection practices, as well as interventions to reduce excessive alcohol use. In line with the Sustainable Development Goals, the identification and elimination of risk factors for liver cancer will be required to achieve a sustained reduction in liver cancer burden. The GBD study can be used to guide these prevention efforts.
Url:
DOI: 10.1001/jamaoncol.2017.3055
PubMed: 28983565
PubMed Central: 5824275
Affiliations:
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Le document en format XML
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<term>Global Burden of Disease (statistics & numerical data)</term>
<term>Global Health (MeSH)</term>
<term>Hepatitis B (complications)</term>
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<term>Consommation d'alcool (épidémiologie)</term>
<term>Enregistrements (MeSH)</term>
<term>Femelle (MeSH)</term>
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<term>Hépatite B (complications)</term>
<term>Hépatite B (épidémiologie)</term>
<term>Hépatite C (complications)</term>
<term>Hépatite C (épidémiologie)</term>
<term>Incidence (MeSH)</term>
<term>Mortalité (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Prévalence (MeSH)</term>
<term>Santé mondiale (MeSH)</term>
<term>Tumeurs du foie (épidémiologie)</term>
<term>Tumeurs du foie (étiologie)</term>
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<term>Hepatitis C</term>
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<term>Hepatitis B</term>
<term>Hepatitis C</term>
<term>Liver Neoplasms</term>
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<term>Hépatite C</term>
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<front><div type="abstract" xml:lang="en"><sec id="ab-coi170064-1"><title>Importance</title>
<p>Liver cancer is among the leading causes of cancer deaths globally. The most common causes for liver cancer include hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and alcohol use.</p>
</sec>
<sec id="ab-coi170064-2"><title>Objective</title>
<p>To report results of the Global Burden of Disease (GBD) 2015 study on primary liver cancer incidence, mortality, and disability-adjusted life-years (DALYs) for 195 countries or territories from 1990 to 2015, and present global, regional, and national estimates on the burden of liver cancer attributable to HBV, HCV, alcohol, and an “other” group that encompasses residual causes.</p>
</sec>
<sec id="ab-coi170064-3"><title>Design, Settings, and Participants</title>
<p>Mortality was estimated using vital registration and cancer registry data in an ensemble modeling approach. Single-cause mortality estimates were adjusted for all-cause mortality. Incidence was derived from mortality estimates and the mortality-to-incidence ratio. Through a systematic literature review, data on the proportions of liver cancer due to HBV, HCV, alcohol, and other causes were identified. Years of life lost were calculated by multiplying each death by a standard life expectancy. Prevalence was estimated using mortality-to-incidence ratio as surrogate for survival. Total prevalence was divided into 4 sequelae that were multiplied by disability weights to derive years lived with disability (YLDs). DALYs were the sum of years of life lost and YLDs.</p>
</sec>
<sec id="ab-coi170064-4"><title>Main Outcomes and Measures</title>
<p>Liver cancer mortality, incidence, YLDs, years of life lost, DALYs by etiology, age, sex, country, and year.</p>
</sec>
<sec id="ab-coi170064-5"><title>Results</title>
<p>There were 854 000 incident cases of liver cancer and 810 000 deaths globally in 2015, contributing to 20 578 000 DALYs. Cases of incident liver cancer increased by 75% between 1990 and 2015, of which 47% can be explained by changing population age structures, 35% by population growth, and −8% to changing age-specific incidence rates. The male-to-female ratio for age-standardized liver cancer mortality was 2.8. Globally, HBV accounted for 265 000 liver cancer deaths (33%), alcohol for 245 000 (30%), HCV for 167 000 (21%), and other causes for 133 000 (16%) deaths, with substantial variation between countries in the underlying etiologies.</p>
</sec>
<sec id="ab-coi170064-6"><title>Conclusions and Relevance</title>
<p>Liver cancer is among the leading causes of cancer deaths in many countries. Causes of liver cancer differ widely among populations. Our results show that most cases of liver cancer can be prevented through vaccination, antiviral treatment, safe blood transfusion and injection practices, as well as interventions to reduce excessive alcohol use. In line with the Sustainable Development Goals, the identification and elimination of risk factors for liver cancer will be required to achieve a sustained reduction in liver cancer burden. The GBD study can be used to guide these prevention efforts.</p>
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